Biography
Dr. Bernard Binetruy is Research Director at Inserm (French governmental agency for medical research).
1980: Master in biochemistry and physiology at the University of Nice.1981-1988: PhD student (1981-1982), then INSERM researcher (1983-1988) at the Centre de Biochimie, Nice (scientifc director Dr F. Cuzin). My research was focused on the oncogenic properties of the Bovine Papilloma Virus type1 (BPV1) in rat embryo fibroblasts.post-doc fellow in the laboratory of Dr M. Karin, department of pharmacology, School of medicine, UCSD, La Jolla, USA. Fellowship of the Fogarty International Center. During my stay in San Diego I showed that the Ras oncogene augments cJun activity and stimulates phosphorylation of its activation domain and that oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of cJun on serines 63 and 73. This work led to the identification and the characterisation, two years later, by the laboratory of M. Karin of the JNK signal transduction pathway.
